The former Tigers champion was drafted with pick no.1 in the 2005 national draft has played 274 AFL games over a stellar 15-year career.
His career accomplishments include winning the Rising Star award in 2005, two All Australians (2012 and 2015) and two Jack Dyer Medals (2008 and 2009).
Deledio joined GWS at the end of the 2016 season but has been hampered by injuries during his time at the expansion club.
“I’m really proud of what I’ve been able to achieve in my career,” he told the Giants club website.
“I’d like to thank the players and staff both past and present at the Richmond footy club, which was my home for over a decade.
“I’m so proud to have played 243 games in the yellow and black and to have achieved two best and fairests and two All Australians there.
“I played my best footy as a Tiger but I’m so grateful for the opportunity the GIANTS presented me at the end of 2016.
“It’s no secret I needed a fresh start and to be able to do that at a new club like the GIANTS has been unbelievable for me.
“I would have loved to have played a lot more footy in the orange guernsey but it wasn’t to be and it taught me the influence I can have on the group without being out on the field.
“I’d like to thank everyone at the GIANTS, particularly the medical staff, for their support over this period.
“The past few years have been really tough, both on and off the field. But it showed me that football isn’t everything and I’m really looking forward to the next chapter of my life with my family.”