Clarke suffered a knock to his knee in the opening centre bounce against the Bulldogs on Sunday.
“He’ll probably miss a couple of weeks,” coach Ross Lyon said.
“It was the first centre bounce of the game, he competed fiercely, knees hit and he stirred up his previous injury.
“He’s pretty sore. I thought it was courageous of him to fight on. He played under adversity and he won’t play this week.”
Meanwhile, the Dockers will welcome back Aaron Sandilands after serving his one match suspension, while defender Michael Johnson is also expected to return after missing last week’s loss with a calf injury.